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Acquisition and loss of tolerance to 1-δ9-trans-tetrahydrocannabinol in rats on an avoidance schedule

✍ Scribed by C. D. Webster; A. E. LeBlanc; Joan A. Marshman; J. M. Beaton

Publisher: Springer
Year: 1973
Tongue: English
Weight: 519 KB
Volume: 30
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00422868

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✦ Synopsis

Daily 12.0 mg/kg intraperitoneal injections of 1-Ag-tetrahydrocannabinol produced tolerance on a number of behavioral measures in rats performing on a discriminated-Sidman avoidance schedule. Tolerance developed during a 9-day drug series and reversed completely during a similar period under vehicle-only injections.