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Acquired von Willebrand syndrome: An update

✍ Scribed by Massimo Franchini; Giuseppe Lippi

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
115 KB
Volume
82
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

Acquired von Willebrand syndrome (aVWS) is a rare bleeding disorder with laboratory findings similar to those for congenital von Willebrand disease (VWD). However, unlike congenital VWD, it arises in individuals with no personal or family history of bleeding. aVWS occurs in association with a variety of underlying disorders, most frequently in lymphoproliferative disorders, myeloproliferative disorders, and cardiovascular diseases. Through an analysis of the more recent literature data, the pathophysiology and the clinical, laboratory, and therapeutic aspects of this syndrome are concisely reported in this review. Am. J. Hematol., 2007. Β© 2006 Wiley‐Liss, Inc.

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✍ Hiroshi Mohri πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 226 KB

Acquired von Willebrand syndrome (AvWS) is not a well-known bleeding disorder among clinicians and is associated with various underlying diseases. The clinical manifestations are similar to congenital von Willebrand disease. Diagnosis is confirmed mainly by a decrease of ristocetin cofactor activity