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Acquired von willebrand disease: Correction of hemostatic defect by high-dose intravenous immunoglobulins

✍ Scribed by Dr. A. Delmer; M. H. Horellou; J. M. Bréchot; J. Prudent; F. Potevin; C. Lecrubier; C. Girard-Longhini; M. Samama; R. Zittoun

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
165 KB
Volume
40
Category
Article
ISSN
0361-8609

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✦ Synopsis

High-dose intravenous immunoglobulins (ivlG) were used in a 57-year-old patient with acquired von Willebrand disease in order to correct a hemostatic defect before pneumonectomy for lung carcinoma. IvlG induced a rapid and complete correction of factor Vlll (F VIII) and von Willebrand factor (vWF) and allowed surgery without additional factor coverage. F Vlll and vWF returned to baseline values within 10 days after ivlG.

📜 SIMILAR VOLUMES

Acquired von Willebrand disease—hemostat
Acquired von Willebrand disease—hemostatic management of major orthopedic surgery with high-dose immunoglobulin, desmopressin, and continuous factor concentrate infusion
✍ Rolf Dario Frank; Dagmar Kunz; Dieter Christian Wirtz 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB

## Abstract Acquired von Willebrand disease (aVWD) is a rare bleeding disorder that mimics congenital VWD in previously healthy individuals; it is most frequently associated with monoclonal gammopathy. Hemostatic therapy of aVWD is challenging due to the extremely shortened half‐life of endogenous