Acquired protein S deficiency

✍ Scribed by Kemkes-Matthes, B.

• Book ID: 104665975
• Publisher: Springer-Verlag
• Year: 1992
• Tongue: English
• Weight: 644 KB
• Volume: 70
• Category: Article
• ISSN: 1432-1440
• DOI: 10.1007/bf00210237

✦ Synopsis

Hereditary deficiencies of coagulation inhibitors like antithrombin III, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach--in part--the extent realised by hereditary protein S deficiency. Thus, acquired protein S deficiencies seem to be one source of thromboembolic complications occurring in nephrotic syndrome, acute phase reactions, malignancy and pregnancy. In this presentation disease states accompanied by acquired protein S deficiency and the mechanisms leading to these alterations are discussed.