✦ LIBER ✦

Acquired bleeding disorder in a patient with malignant lymphoma : Antibody-mediated prothrombin deficiency

✍ Scribed by Edmond S. Lee; Bradley K. Hibsman; Howard A. Liebman

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 102 KB
Volume: 91
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20010215)91:4<636::aid-cncr1046>3.0.co;2-v

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✦ Synopsis

BACKGROUND.

Bleeding manifestations secondary to acquired hemostatic abnormalities in cancer patients have been well described. Bleeding due to the development of hemostatic inhibitors is observed less frequently. In this report, the authors describe a patient with a low grade lymphoma who presented with an acquired bleeding disorder and abnormal hemostatic screening tests.

METHODS.

Patient plasma samples were collected initially and during the course of treatment. Mixing studies and specific coagulation factor assays were performed to detect and confirm any deficiencies. Patient immunoglobulin G was isolated from plasma, and binding to prothrombin was demonstrated by immunoblot method and enzyme-linked immunosorbent assay (ELISA) techniques.

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