## Abstract Kv3.1, a voltageβdependent potassium channel, has two forms, βa and βb, which differ in expression during development and at the onset of function in the auditory system. To determine whether cochlear nerve input could affect the expression of these two forms, cultures of the developing
Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons
β Scribed by Song, Ping; Yang, Yue; Barnes-Davies, Margaret; Bhattacharjee, Arin; Hamann, Martine; Forsythe, Ian D; Oliver, Douglas L; Kaczmarek, Leonard K
- Book ID
- 109940680
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 813 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1097-6256
- DOI
- 10.1038/nn1533
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## Abstract The present study traces the development of a voltageβdependent potassium channel protein (Kv3.1) in the avian homologue of the cochlear nucleus, in the cochleovestibular ganglion, and in the otic epithelium from early developmental stages until near hatching. Immunohistochemistry with
The Kv3.1 potassium channel gene is expressed in neurons that fire action potentials at high frequencies. Neurons that express this gene, such as auditory brain stem neurons, have high-threshold voltage-dependent potassium currents that activate and deactivate unusually rapidly, and whose characteri