Acospectoside a II: The structure of the cardenolide glycoside

✍ Scribed by Govind J. Kapadia

• Book ID: 102399378
• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 334 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600581235

✦ Synopsis

The structure of acospectoside A, a new cardenolide bioside isolated from Acokuntheru ublungifuliu, was elucidated by studying the various hydrolysis products. Anhydroacovenosigenin A, acovenosigenin A, D-glucose, and L-acovenose resulted from mineral acid hydrolysis. Enzymatic hydrolysis furnished acovenosides A and B, acobioside A, and D-glucose. These and other results showed that acospectoside A is 1-0-acetyl-acobioside A. The findings were confirmed by acetylating acospectoside A and acobioside A to yield the same hexa-0-acetyl-acobioside A which with mild alkaline hydrolysis afforded acospectoside A.

Keyphrases 0 Acospectoside A-structure determination Hydrolysis products, formation-acospectoside A structure determination 0 Cardiotoxicity-acospectoside A 0 Cytotoxicityacospectoside A 0 TLC-separation, identification 0 IR spectrophotometry-structure 0 NMR spectroscopy-structure