✦ LIBER ✦
Aconitase (E.C. 4.2.1.3) mitochondrial locus mapped to human chromosome 22: Studies with Chinese hamster-human somatic cell hybrids
✍ Scribed by Robert S. Sparkes; T. Mohandas; Maryellen C. Sparkes; Jeffery D. Shulkin
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 288 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0006-2928
No coin nor oath required. For personal study only.
✦ Synopsis
Three separate somatic cell fusions were made between Chinese hamster lines and human lymphocytes containing (1) a 3/4 translocation, (2) an X/9 translocation, and (3) a 17/9 translocation. Eleven independently derived hybrids showed that only human chromosome 22 was consistently present when human ACONM was expressed and absent when human ACONM was not expressed. These studies assign a gene for human ACONM to chromosome 22, and are consistent with prior gene-mapping results.