[ACM Press the First ACM International Conference - Niagara Falls, New York (2010.08.02-2010.08.04)] Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology - BCB '10 - Applying graph theoretic approaches to microbial metagenomes

✍ Scribed by Hankeln, Wolfgang; Buttigieg, Pier Luigi; Kostadinov, Ivaylo; Kottmann, Renzo; Yilmaz, Pelin; Duhaime, Melissa Beth; Glöckner, Frank Oliver

• Book ID: 120836390
• Publisher: ACM Press
• Year: 2010
• Weight: 576 KB
• Category: Article
• ISBN: 1450304389
• DOI: 10.1145/1854776.1854863

✦ Synopsis

Graph theoretic approaches of fer a powerful means to visualise and examine data arising from microbial environmental metagenomes. Here, inter-correlations of protein domains with no known function detected in marine microbial metagenomes were visualised as networks. The topology of these networks combined with putative functional assignments of some participant protein domains allowed the generation of hy potheses concerning the ecological functions these networks may reveal. These methods may be employed to offer an ecological pers pective in future attempts to describe the function of uncharacterised protein domains.