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Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death

✍ Scribed by Aoyama, Koji; Burns, David M; Suh, Sang Won; Garnier, Philippe; Matsumori, Yasuhiko; Shiina, Hiroaki; Swanson, Raymond A

Book ID
110046419
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
495 KB
Volume
25
Category
Article
ISSN
0271-678X

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## Abstract Astrocytes are essential cells for maintaining brain integrity. We have recently shown that the transcription factor C/EBP homologous protein (CHOP), associated with endoplasmic reticulum (ER) stress, plays a key role in the astrocyte death induced by ischemia. Meanwhile, mediators of a