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Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death

โœ Scribed by Yi-Zhi Wang; Tian-Le Xu

Book ID
107582738
Publisher
Springer
Year
2011
Tongue
English
Weight
433 KB
Volume
44
Category
Article
ISSN
0893-7648

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High doses of salicylate and aspirin are
High doses of salicylate and aspirin are inhibitory on acid-sensing ion channels and protective against acidosis-induced neuronal injury in the rat cortical neuron
โœ Wei Wang; Shan-Dong Ye; Ke-Qing Zhou; Li-Min Wu; Yi-Na Huang ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 252 KB ๐Ÿ‘ 1 views

## Abstract Aspirin and its main metabolite salicylate are widely used to relieve pain, treat inflammatory diseases, and prevent ischemic stroke. Multiple pathways are responsible for the therapeutic actions exerted by these drugs. One of the pathways is targeting neuronal receptors/ion channels in