Acidic phospholipids, diacylglycerols, and free fatty acids in gerbil brain: A comparison of ischemic changes resulting from carotid ligation and decapitation
✍ Scribed by S. F.-L. Huang; Dr. G. Y. Sun
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 552 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
The levels of brain acidic phospholipids (poly-PI, PI, quent studies further indicated that this phenomenon is PA, and PS), DG, and FFA and their acyl group common to other types of drug-induced convulsion profiles were determined after induction of ischemia [Siesjo et al, 1982; Rodriguez de Turco et al, 19831. FFA in gerbils by ligation of the common carotid arteries release is also observed in cerebral ischemia resulting and decapitation. Ischemia induced by both procefrom ligation of the common carotid arteries [De Medio dures resulted in a significant decrease in poly-PI et al, 1980; Yoshida et al, 1983; Bhakoo et al, 19841. (20% for 1-min decapitation and 1-min ligation). Ex-Although the exact mechanism for the FFA release recept for a 16% increase in PI in the 5-min decapitation mains to be delineated, discernible differences in the group, no apparent change was found in other phosrelease patterns are shown in different brain regions pholipids after either ischemic condition. The level of [Bhakoo et al, 19841 and in different cerebral hemi-DG was increased one-and threefold after 1 and 5 spheres [Pediconi and Rodriguez de Turco, 19841. Postmin, respectively, of decapitative ischemic treatment. decapitative ischemic treatment of rats has indicated a Ligation of the carotid arteries for 1 min resulted also biphasic mode of FFA release. During the initial phase, in a onefold increase in the DG level. The decapitative arachidonic and stearic acids are preferentially released model resulted in a one-and fivefold increase in FFA [Tang and Sun, 1982; Yasuda et al, 19851. The biphasic level (with respect to 1 and 5 min, respectively), mode suggests that more than one biochemical mechawhereas ligation for 1 min resulted in an increase of nism is responsible for the FFA release owing to decap-42% of the FFA. The acyl groups of poly-PI and PI in itation. the control gerbil brain are enriched in 18:O and 20:4, Cerebral ischemia also induces an increase in the but those of DG, FFA, and PA have a higher propordiacylglycerol (DG) level in brain [