๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Acidic fibroblast growth factor (aFGF) is expressed in the neuronal and glial spinal cord cells of adult mice

โœ Scribed by Dr. A. Tourbah; L. Oliver; J. C. Jeanny; M. Gumpel

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
916 KB
Volume
29
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

โœฆ Synopsis

Fibroblast growth factors (FGFs) are known to be synthesized in the central nervous system (CNS) and to act on CNS cells in vitro, but less is known about their synthesis, expression, and role in vivo. In this work, using specific anti-acidic fibroblast growth factor (aFGF) antibodies, we have shown for the first time, by immunohistochemistry, that aFGF is expressed in spinal cord cells of young adult normal mice. This expression is predominant in the cell nucleus. Using immunohistochemical double staining procedures, we identified the cell type expressing aFGF as neurons, astrocytes, and oligodendrocytes, but for each type, cells were not all positively immunostained.

๐Ÿ“œ SIMILAR VOLUMES

Fibroblast growth factor-2 mRNA expressi
Fibroblast growth factor-2 mRNA expression in the brainstem and spinal cord of normal and chronic spinally transected urodeles
โœ Marie Moftah; Marc Landry; Frรฉdรฉric Nagy; Jean-Marie Cabelguen ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 454 KB ๐Ÿ‘ 1 views

## Abstract Descending pathways in the spinal cord of adult urodele amphibians show a high regenerative ability after body spinal cord transection; regenerated axons regrow into the transected spinal cord, and hindlimb locomotor recovery occurs spontaneously. Little is currently known about the mol

Effects of acidic and basic fibroblast g
Effects of acidic and basic fibroblast growth factors (aFGF and bFGF) on the proliferation and the glutamine synthetase expression of rat astroblasts in culture
โœ Frรฉdรฉric Perraud; Franรงois Besnard; Brigitte Pettmann; Monique Sensenbrenner; Gรฉ ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 851 KB

The two fibroblast growth factors called acidic and basic FGF (aFGF and bFGF) show a strong homology (55%) of their amino acid sequence (Esch et al.: Proc. Nat. Acad. Sci. USA 85:6507-6511, 1985). The effects of these factors on the rate of proliferation of rat astroblasts and on the expression of g

A combination of insulin-like growth fac
A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord
โœ Martin Oudega; Xiao Ming Xu; Vรฉronique Guรฉnard; Naomi Kleitman; Mary Bartlett Bu ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 290 KB ๐Ÿ‘ 1 views

Insulin-like growth factor-I (IGF-I) promotes axonal regeneration in the peripheral nervous system and this effect is enhanced by platelet-derived growth factor (PDGF). We decided, therefore, to study the effects of these factors on axonal regeneration in the adult rat spinal cord. Semipermeable pol