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Acid—base equilibria of β-blockers in acetonitrile

✍ Scribed by J. Barbosa; V. Sanz-Nebot; M.E. Torrero

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
230 KB
Volume
8
Category
Article
ISSN
0731-7085

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✦ Synopsis

The acid-base equilibria of a series of beta-adrenoceptor blocking drugs in acetonitrile have been studied, and pKHB+ values determined. The theory of such titrations is discussed and simple potentiometric and visual methods in acetonitrile media are proposed for the assay of beta-adrenoceptor blocking drugs.

📜 SIMILAR VOLUMES

Acid-base equilibria in acetonitrile-wat
Acid-base equilibria in acetonitrile-water mixtures: Selection of conditions for titration of bases
✍ Georgi Velinov; Darvin Ivanov; Omortag Budevsky 📂 Article 📅 1974 🏛 Elsevier Science ⚖ 306 KB

Acetonitrile (AN) is widely used as a solvent for titration in nonaqueous media, because many organic and inorganic compounds are soluble in it. Moreover the solvent has a long pH-scale and pronounced differentiating properties. It can be purified easily and has a low toxicity. The acid-base equili