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Acid catalyzed α-alkylation of β-aminothiophenes with aldehydes. synthesis of 2-alkyl 3-thiophenamines, bis(3-amino-2-thienyl)-methane derivatives and dithieno[3,2-b:2′,3′-e]pyridines

✍ Scribed by M'Hamed Berkaoui; Francis Outurquin; Claude Paulmier


Book ID
112131418
Publisher
Journal of Heterocyclic Chemistry
Year
1996
Tongue
English
Weight
459 KB
Volume
33
Category
Article
ISSN
0022-152X

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N-(3-Benzo[b]thienyl)iminophosphoranes t
✍ Carlo Bonini; Lucia Chiummiento; Maria Funicello; Piero Spagnolo 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 92 KB

The novel N- (3-benzo[b]thienyl)iminophosphoranes 1b-d react with a,b-unsaturated aldehydes and ketones 2a-e to give varying mixtures of the regioisomeric benzothieno[3,2-b]pyridines 3a-d and 4a-d as a result of preferential attack of either imino nitrogen or a-thienyl carbon at the enone carbonyl g