Acid-catalyzed rearrangement of O-(2-arylphenyl)hydroxylamines to aryldihydroazepinones

✍ Scribed by Yasuyuki Endo; Ken-ichiro Kataoka; Naoki Haga; Koichi Shudo

• Book ID: 104225083
• Publisher: Elsevier Science
• Year: 1992
• Tongue: French
• Weight: 235 KB
• Volume: 33
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)92083-5

✦ Synopsis

Acid-catalyzed rearrangement of 0-(2-arylphenyl)hydroxylamines followed by ring enlargement affords 7-aryl-2,3-dihydro-lH-azepin-2-ones. 2-Amino-2-phenyl-3,5-cyclohexadienone, an intermediate of the reaction, was trapped as the N-trifluoroacetamide.