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Acid-Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: An Investigation on the Synthesis of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters

โœ Scribed by Dudley, Matthew E.; Morshed, Md. Monzur; Brennan, Courtney L.; Islam, M. Shahidul; Ahmad, M. Syarhabil; Atuu, Mary-Rose; Branstetter, Bryan; Hossain, M. Mahmun


Book ID
126833100
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
189 KB
Volume
69
Category
Article
ISSN
0022-3263

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## Hydroxycarboxylic acids (ether carboxylic acids) and esters Q 0450 Acid-Catalyzed Reactions of Aromatic Aldehydes with Ethyl Diazoacetate: An Investigation on the Synthesis of 3-Hydroxy-2-arylacrylic Acid Ethyl Esters. -High yields of the biologically important 3-hydroxy-2-arylacrylates can be

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Ethyl diazoacetate reacts with a variety of aldehydes in the presence of a Lewis acid catalyst to give either [~-keto esters or a-formyl esters, the types of products mainly depending upon the nature of Lewis acid catalysts employed. Reactions catalyzed by Lewis acids such as SnCI2 and SnCl4 provide