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Acid-catalyzed cyclocondensation of nitriles. III. Synthesis of substituted 3-aminoisoquinolines and study of their cytotoxicity

โœ Scribed by G. B. Lapa; V. O. Tolkachev; T. P. Ivanova; O. N. Tolkachev


Book ID
112713398
Publisher
Springer
Year
1996
Tongue
English
Weight
242 KB
Volume
30
Category
Article
ISSN
0091-150X

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A mild cross-coupling reaction has been used to access several N-vinyl substituted indoles. When treated with acid, these unique enamines produce novel dimeric and trimeric products derived from a preferred protonation reaction at the enamine p-bond.