✦ LIBER ✦
Acid catalysed reactions between diols and vinyl-ethers in basic solvents towards a selective protection of polyols by 2,3-dihydro-4H-pyran
✍ Scribed by Robert Nouguier
- Book ID
- 104220973
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 127 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Acid catalysed synthesis of THP ethers of 1,3-butanedlol takes place much more selectively and ln hlqh yields lf DMSO is used as solvent, instead ln CHC13, even with mild acid catalysts, rearranqed 1,3-dloxans are obtained In an attempt to orepare alkylated sugar derivatives from oartlally tetrahydrooyranylated intermediates', we have found that the nature of the solvent olays a orominent part in the protection of alcohol functions. In order to rationalize these results on a simple model we have studied the acid catalysed reaction between 1,3-butanedloliand2,3-dlhydro-4H-pyran