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Achiral Ligands Dramatically Enhance Rate and Enantioselectivity in the Rh/Phosphoramidite-Catalyzed Hydrogenation of α,β-Disubstituted Unsaturated Acids

✍ Scribed by Rob Hoen; Jeroen A. F. Boogers; Heiko Bernsmann; Adriaan J. Minnaard; Auke Meetsma; Theodora D. Tiemersma-Wegman; André H. M. de Vries; Johannes G. de Vries; Ben L. Feringa

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 285 KB
Volume: 44
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200500784

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Achiral Ligands Dramatically Enhance Rat

Achiral Ligands Dramatically Enhance Rate and Enantioselectivity in the Rh/Phosphoramidite-Catalyzed Hydrogenation of α,β-Disubstituted Unsaturated Acids

✍ Rob Hoen; Jeroen A. F. Boogers; Heiko Bernsmann; Adriaan J. Minnaard; Auke Meets 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

In 2000, three research groups demonstrated that the widely held view that chiral bidentate ligands are necessary to achieve high enantioselectivity in rhodium-catalyzed hydrogenations needs revision. Monodentate phosphonites, [1a] phosphites [1b] and phosphoramidites [1c] proved to be highly versat