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Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils

✍ Scribed by Alejandra Alvarez; Carlos Opazo; Rodrigo Alarcón; Jorge Garrido; Nibaldo C Inestrosa


Book ID
115628108
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
844 KB
Volume
272
Category
Article
ISSN
0022-2836

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## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state