Acetylcholine receptor turnover in clonal muscle cells: Role of plasmin and effects of protease inhibitors

Critical role of both p27KIP1and p21CIP1

Critical role of both p27KIP1and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 (‘Iressa’), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells

✍ Elena Di Gennaro; Marcella Barbarino; Francesca Bruzzese; Sonya De Lorenzo; Mich 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB 👁 1 views

## Abstract High expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of squamous‐cell carcinomas of head and neck (SCCHN). ZD1839 (‘Iressa’) is an orally active, selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways