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Acetylcholine and epinephrine effects on the embryonic rat heart

โœ Scribed by Hall, E. K.

Publisher
Wiley (John Wiley & Sons)
Year
1957
Tongue
English
Weight
625 KB
Volume
49
Category
Article
ISSN
0095-9898

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โœฆ Synopsis

The effects of acetylcholine and of epinephrine upon the embryonic heart appear to be of special interest, since they are not complicated by possible effects of the drugs on intrinsic nerve cells and fibers and on vessels, as in experimentation on the adult heart.

I n the present investigation, acetylcholine ( ACh) and epinephrine were tested on isolated embryonic rat hearts and their fragments at stages (10+-13& days) which precede the invasion of nerve cells and fibers. Additional hearts were used at a stage (143 days) immediately after such invasion. It was found that both ACh and epinephrine acted directly upon the embryonic rat myocardium.

Methods

The materials and methods were in general those of previous investigations (Hall, '51, '54, '55). Pregnant rats of the Sprague-Dawley strain were anesthetized with sodium barbital (220-300 mg/kg) and the embryos were removed

๐Ÿ“œ SIMILAR VOLUMES

Atropine effects on the embryonic rat he
Atropine effects on the embryonic rat heart
โœ Hall, E. K. ๐Ÿ“‚ Article ๐Ÿ“… 1959 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 475 KB ๐Ÿ‘ 1 views

## T W O FIGURES There is diversity of opinion as to the nature of action of atropine on cardiac muscle. It is stated in some texts that atropine has slight and insignificant direct effects, in others. that small doses stimulate but that large doses depress. Nearly all authors agree that, in block