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Acetylation phenotypes and environmental chemical exposure of people with idiopathic systemic lupus erythematosus

✍ Scribed by Marcus M. Reidenberg; Dennis E. Drayer; Beverly Lorenzo; Brian L. Strom; Suzanne L. West; Ellen S. Snyder; Bruce Freundlich; Paul D. Stolley

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
336 KB
Volume
36
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

To test the hypotheses that there is an excess percentage of slow acetylators among patients with idiopathic systemic lupus erythematosus (SLE) and that these patients had excessive exposure to environmental amines and hydrazines before the onset of illness.

Methods. Case-control study with structured interview and acetylation phenotyping.

Results. No excess proportion of slow acetylators or environmental amine exposure was found.

Conclusion. Slow acetylation phenotype and exposure to environmental amines are not principal causes of idiopathic SLE.

Perry et al, in 1970, first reported a high proportion of genetic slow acetylators among patients with hydralazine-induced systemic lupus erythemato-From the Departments of Pharmacology and Medicine,

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