Acetylation and acetoxylation of 4-hydroxy-1,4-benzothiazin- and -benzoxazin-3(4H)-ones (cyclic hydroxamic acids)
โ Scribed by Coutts, R. T.; Pound, N. J.
- Book ID
- 120878313
- Publisher
- The Royal Society of Chemistry
- Year
- 1971
- Tongue
- English
- Weight
- 514 KB
- Category
- Article
- ISSN
- 0022-4952
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๐ SIMILAR VOLUMES
3.1-Benzothiazin-4-ones are sulfur analogs of the potent serine protease inactivators of the 3,1-benzoxazin-4-one type. which acylate the serine residue within the active site of the enzymes. A series of 2-amino-3,1-benzothiazinones was synthesized, but these compounds showed only very little inhibi
The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th