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Acetone-induced potentiation of trihalomethane toxicity in male rats

โœ Scribed by Hewitt, William R.; Brown, Esther M.; Plaa, Gabriel L.


Book ID
122120398
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
670 KB
Volume
16
Category
Article
ISSN
0378-4274

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Male Sprague-Dawley rats, injected with the irreversible acetylcholinesterase (AChE) inhibitor soman (pinacolyl methylphosphonofluoridate) 25 micrograms/kg sc, showed no signs of toxicity. Pretreatment with iso-OMPA (tetraisopropylpyrophosphoramide) 1 mg/kg sc 1 h before the soman administration, ca