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Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study

✍ Scribed by William J. Holubek; Susanne Kalman; Robert S. Hoffman

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 42 KB
Volume: 43
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.21106

No coin nor oath required. For personal study only.

✦ Synopsis

In addition to the hypothetical liver vulnerability of homozygous CCR5-⌬32 patients, it seems that CCR5 de ficiency may increase the susceptibility to other diseases. Preliminary results from our laboratory also suggest that CCR5-deficient mice disclose higher susceptibility to experimental pancreatitis. 9 This may explain why CCR5-⌬32 mutation represents only a small minority of the population in most parts of the world.

The recent observation of a hepatotoxic adverse event in patients treated with CCR5 inhibitors is consistent with our experimental observations. As pointed by S. Mauss and M. Puoti, HIV patients are frequently exposed to other hepatotoxic agents (virus, alcohol, drugs). The hypothetical vulnerability of patients with CCR5 deficiency must be kept in mind for the future use of CCR5 inhibitors.

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