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Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double-blind placebo-controlled trial

✍ Scribed by Stephen E Wang; Primo N. Lara Jr.; Angie Lee-Ow; Jeanne Reed; Lori R. Wang; Patti Palmer; Joseph M. Tuscano; Carol M. Richman; Laurel Beckett; Ted Wun

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 52 KB
Volume: 70
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.10119

No coin nor oath required. For personal study only.

✦ Synopsis

Non-hemolytic transfusion reactions (NHTR) occur in up to 30% of patients receiving platelet transfusions. Premedication with acetaminophen and diphenhydramine is a common strategy to prevent NHTR, but its efficacy has not been studied. In this prospective trial, transfusions in patients receiving pre-storage leukocyte-reduced single-donor apheresis platelets (SDP) were randomized to premedication with either acetaminophen 650 mg PO and diphenhydramine 25 mg IV, or placebo. Fifty-one patients received 98 transfusions. Thirteen patients had 15 NHTR: 15.4% (8/52) in the treatment arm and 15.2% (7/46) in the placebo arm. Premedication prior to transfusion of pre-storage leukocyte reduced SDP does not significantly lower the incidence of NHTR as compared to placebo.

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