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Acetals of lactams and acid amides. 48. Reaction of enamino diketones with amide crystals. Synthesis of derivatives of coumarin and carbostyril

โœ Scribed by V. G. Grannik; A. K. Shanazarov; N. P. Solov'eva; V. V. Chistyakov; I. V. Persianova; Yu. N. Sheinker


Publisher
Springer US
Year
1987
Tongue
English
Weight
595 KB
Volume
23
Category
Article
ISSN
0009-3122

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The reaction of substituted 3-acetylbenzofurans with dimethylformamide diethylacetal gave the corresponding enaminoketones, which reacted with p-benzoquinone to give bis(benzofuryl.3 )ketone derivatives.

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6, 7, reacted similarly with hydroxylamine hydrochloride. The yields of oximes lllc and IVc in this case were 29% and 45%, respectively. 2-Phenyl-5-oxo-5,6~7~8-tetrahydroquinoline (V). This compound was obtained in 85% yield by the method in [3] from 3 g (0.0123 mole) of 2-[3-phenyl-3-oxopropyl]