Accurate prediction of death by serial determination of galactose elimination capacity in primary biliary cirrhosis: A comparison with the mayo model
✍ Scribed by Prof. Jürg Reichen; Thomas Widmer; Jacques Cotting
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 662 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
We retrospectively analyzed the predictive accu-obtained and do not include histological criteria. racy of serial determinations of galactose elimi-Moreover, the model has been validated in populations nation capacity in 61 P a F n t s with Primary biliary independent of those leading to the initial formulation ClrrhOsfS. Death W a s PF:*cted from !he t!me that the (13,161. Although the Mayo model appears to be robust, regresslon llne descnblng the decline 1 x 1 galactose Some of its parameters (including serum bilirubin, elimination capacity vs. time intersected a value of prothrombin time and albumin level) could be affected 4 mg min-' * kg-'. Thirty-one patients exhibited deby extrahepatic factors. Moreover, it is most accurate creasing galactose elimination capacity; in 11 patients it stable and in 19 patients odyone value w8s shortly before the patient's death; this is sufficient for available. Among those patients with decreasing ga-the Optimal timing Of orthotopic liver tranSplantatiOn lactose elimination capacity, 10 died and three un-but does not permit assessment of pharmacological dement liver transplantation; prediction of death was interventions in patients with less-advanced disease. accurate to 7 * 19 mo. This criterion incorrectly pre-Finally, the applicability to individual patients may be dicted death in two patients with portal-vein throm-less than ideal (17). bosis; otherwise, it did better than or as well 8s the Dynamic liver function tests such as galactose elimi-Mayo clinic score. The latter was also tested on our nation capacity (GEC) or the minopyrine