Accurate, localized quantification of white matter perfusion with single-voxel ASL

✍ Scribed by Rolf Pohmann

• Book ID: 102533979
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 285 KB
• Volume: 64
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.22476

✦ Synopsis

Abstract

Quantification of perfusion in white matter is still difficult due to its low level, causing an often insufficiently low signal‐to‐noise ratio, and its long and inhomogeneous transit delays. Here, a technique is presented that accurately measures white matter perfusion by combining a spectroscopic single‐voxel localization technique (point‐resolved spectroscopy) with a pulsed arterial spin labeling encoding scheme (flow‐sensitive alternating inversion recovery) to specifically address the properties of white matter. The transit delay was measured by shifting the position of a slice‐selective saturation pulse between inversion and acquisition. Perfusion measurements resulted in values of 15.6 ± 3.2 mL/100 g/min in the left and 15.2 ± 4.8 mL/100 g/min in the right hemispheric white matter and 83.2 ± 15.2 mL/100 g/min in cortical gray matter. Taking dispersion of the transit times into account does not cause a significant change in the measured values. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.