## Abstract Matrixβassisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) timeβofβflight mass spectrometry (TOFMS) play an essential role in the analysis of biological molecules, not only peptides and proteins, but also DNA and RNA. Tandem mass spectrometry used for sequence
Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass spectrometry
β Scribed by Charles A. Barnes; Norman H.L. Chiu
- Book ID
- 108146620
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 603 KB
- Volume
- 279
- Category
- Article
- ISSN
- 1387-3806
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A novel tandem time-of-flight (TOF) mass spectrometer has been developed for studying the photo-induced dissociation of large molecules and elemental clusters. It consists of a linear first stage TOF analyser for primary mass separation and precursor ion selection, and a second orthogonal reflecting
## Abstract Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2β²βdeoxyguanosine. This adduct has been detected in rat and human