Accurate assay of enantiopurity of 1-hydroxy- and 2-hydroxyalkylphosphonate esters
✍ Scribed by Ewa Żymańczyk-Duda; Mariusz Skwarczyński; Barbara Lejczak; Pawel Kafarski
- Book ID
- 108036432
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 204 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
The peracid oxidation of methyl 2-(t-butyldimethylsilyloxy)-7.alkcnoates 2 furnished the corresponding epoxides 3 in good yields.The regiospecific opening of the latter compounds with methanol afforded 3-hydroxy Z-acetal-esters 4. When alkyl disuhstitnted in position 3, compounds 3 or 4 could be dep
## Abstract The title compound __R__‐4a was prepared from (–)‐quinic acid (1) in 6 steps in 18% overall yield (Scheme 3) and with 100% enantiomeric purity (Figure 1). The initiating step is the regio‐ and stereoselective acetalization of the __trans__‐oriented vicinal OH groups of 1 (+ 5 → 8). Alco