Accurate apoptosis measurement requires quantification of loss of expression of surface antigens and cell fragmentation

Downregulation of rheumatoid arthritis-r

Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9

✍ Takako Hattori; Klaus von der Mark; Harumi Kawaki; Yasutaka Yutani; Satoshi Kubo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 646 KB

## Abstract Previously, we showed that gene expression of the rheumatoid arthritis‐related antigen RA‐A47, which is identical to human heat shock protein (HSP)47, was downregulated in chondrocytes by inflammatory cytokines such as TNFα. Associated with this phenomenon, RA‐A47 appeared on the cell s