Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T1 measurements
✍ Scribed by Greg O. Cron; Giles Santyr; Frederick Kelcz
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 160 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
A method is presented that converts dynamic T 1 -weighted spoiled gradient-recalled echo (SGRE) image intensities into estimates of T 1 without the errors associated with imperfections in the slice profile and transmitter coil magnetic field (B 1 ). The method involves T 1 measurements performed before and after a series of dynamic SGRE images. These measurements serve to calibrate and correct the SGRE signal strength equation used to estimate T 1 . Simulations and phantom experiments were performed to test the method for slice-selective (two-dimensional) and slab-selective (three-dimensional) imaging, as well as for imaging performed with optimized and un-optimized B 1 . For nearly all test conditions, T 1 was estimated accurately (within 10%) over a range of T 1 values expected in vivo (D1200 = 300 msec). This method should be useful for quantifying dynamic SGRE imaging for many different applications including breast MR imaging.