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Accurate and Precise Measurement of Heteronuclear Long-Range Couplings by a Gradient-Enhanced Two-Dimensional Multiple-Bond Correlation Experiment

✍ Scribed by Shuqun Sheng; Herman van Halbeek

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 119 KB
Volume: 130
Category: Article
ISSN: 1090-7807
DOI: 10.1006/jmre.1997.1318

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✦ Synopsis

We propose a phase-sensitive gradient-enhanced two-dimensional heteronuclear multiple-bond correlation (psge-2D HMBC) experiment for speedy, accurate, and precise measurement of 2JCH and 3JCH. The experiment does not suppress one-bond correlations. Rather, the value of a desired long-range JCH is obtained from the pertinent cross-peak pattern in the HMBC spectrum, using the corresponding 1JCH correlation pattern as reference. The application of the proposed experiment is illustrated for the trisaccharide raffinose.

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