Accuracy of blood volume estimations in critically I11 children using125I-labelled albumin and51Cr-labelled red cells

✍ Scribed by O. Linderkamp; H. Holthausen; J. Seifert; I. Butenandt; K. P. Riegel

• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 478 KB
• Volume: 125
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00489987

✦ Synopsis

Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893+/-0.018 (SD) in the children with sepsis, 0.859+/-0.052 in the burned patients, and 0.916+/-0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.