Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is common t o many human carcinomas, including those of the colon and prostate. It localizes to two discrete regions, 8p21 and 8p22. This suggests the presence of at least two tumor suppressor genes (TSGs) on this chromosome arm. H
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Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity
โ Scribed by Wei-Wen Jiang; Hiroaki Fujii; Toshikazu Shirai; Hiroko Mega; Minoru Takagi
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 564 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0008-543X
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Deletions involving the chromosome 9p21 region have been reported as frequent events in non-small cell lung cancer (NSCLC). To investigate potential tumor-suppressor gene (TSG) loci within the 9p21 region, which also harbors the candidate TSG locus CDKN2a, we studied 32 cases of primary NSCLC for lo