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Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

✍ Scribed by David R. Borchelt; Michael K. Lee; Victoria Gonzales; Hilda H. Slunt; Tamara Ratovitski; Nancy A. Jenkins; Neal G. Copeland; Donald L. Price; Sangram S. Sisodia


Book ID
117412225
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
244 KB
Volume
23
Category
Article
ISSN
0197-4580

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## Abstract A recent report showed that the accumulation of α‐synuclein (α‐syn) was detected in the brains of one‐third of Alzheimer's disease and Down syndrome patients. However, the relationship between amyloid‐β protein (AΞ²) and α‐syn remains unclear. We analyzed the relation between the mutatio