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Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure

✍ Scribed by Ewa M. Slominska; Katarzyna Kowalik; Ryszard T. Smolenski; Marek Szolkiewicz; Przemyslaw Rutkowski; Boleslaw Rutkowski; Julian Swierczynski

Publisher
Springer
Year
2006
Tongue
English
Weight
202 KB
Volume
21
Category
Article
ISSN
0931-041X

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## Abstract Temozolomide (TZM) is a novel methylating agent currently under investigation for treatment of recurrent high‐grade gliomas. Although TZM generates a wide spectrum of methyl adducts, its cytotoxicity has been attributed to mismatch repair (MR)‐mediated processing of O^6^‐methylguanine:T