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Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats

✍ Scribed by Jimmy W. Crott; Sang-Woon Choi; Richard F. Branda; Joel B. Mason


Book ID
113808519
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
182 KB
Volume
570
Category
Article
ISSN
0027-5107

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## Abstract By using a combination of Southern blot hybridization analysis, polymerase–chain reaction amplification, and direct nucleotide sequencing, we studied deletions of mitochondrial DNA (mtDNA) in several nonfamilial patients with progressive external ophthalmoplegia and Kearns‐Sayre syndrom