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Accumulation of mitochondrial DNA deletions in human oral tissues — effects of betel quid chewing and oral cancer

✍ Scribed by Hsin-Chen Lee; Pen-Hui Yin; Tzu-Ning Yu; Yeong-Dar Chang; Wen-Chen Hsu; Shou-Yen Kao; Chin-Wen Chi; Tsung-Yun Liu; Yau-Huei Wei

Book ID
117766709
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
181 KB
Volume
493
Category
Article
ISSN
1383-5718

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## Abstract Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to oxidative DNA damage and limited repair mechanisms. For investigation of the potential role of somatic mtDNA mutations in the tumorigenesis of oral cancer, we screened the