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Accumulation of labelled vitamin B12 in some transplanted tumours

✍ Scribed by Hans Flodh; Sven Ullberg

Publisher: John Wiley and Sons
Year: 1968
Tongue: French
Weight: 437 KB
Volume: 3
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910030518

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✦ Synopsis

ThcJ accumulation of labelled vitamin B,, in four different kinds of transplanted r1tmour was studied iising whole-body autoradiography and impulse counting. The runlours were g'Sr-induced soft fibroblastic osteosarcomas, spontaneous mamniary carcinonias, Ehrlich ascites and Moloney virus-induced tumours. The goSr-induced soft sarcoma, which was the most rapidly growing tutnour, showed the greatest uptake of radio-BI2, the concentration being higher than in any normal tissue. In all turnours the radioactivity was focalized to the peripheral, still activefy growing parts. It is suggested that a connection exists between growth rate and accumulation of B,, and that BIL is needed for rapid cell multiplication.

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