Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure

Incidence and effects of Ha-ras codon 12

Incidence and effects of Ha-ras codon 12 G→A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus

✍ Beth W. Liston; Ashok Gupta; Ronald Nines; Peter S. Carlton; Laura A. Kresty; Ga 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 440 KB

N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis is an important model for squamous cell carcinoma of the human esophagus. In this model, previous studies have shown that the GGA-->GAA Ha-ras codon 12 mutation is present in the majority of papillomas. No other Ha-ras mutation h