𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Accumulation of hypoxia-inducible factor-1α is limited by transcription-dependent depletion

✍ Scribed by Demidenko, Zoya N; Rapisarda, AnnaMaria; Garayoa, Mercedes; Giannakakou, Paraskevi; Melillo, Giovanni; Blagosklonny, Mikhail V

Book ID
110069686
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
241 KB
Volume
24
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Quercetin suppresses hypoxia-induced acc
Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis
✍ Dae-Hee Lee; Yong J. Lee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1α (HIF‐1α) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i

Flavonoids-induced accumulation of hypox
Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1α/2α is mediated through chelation of iron
✍ Sung-Soo Park; Insoo Bae; Yong J. Lee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

## Abstract Hypoxia‐inducible factor‐1 alpha (HIF‐1α) is the regulatory subunit of the heterodimeric transcription factor HIF‐1 that is the key regulator of cellular response to low oxygen tension. Under normoxic conditions, HIF‐1α is continuously degraded by the ubiquitin‐proteasome pathway throug