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Accumulation of genetic alterations and their significance in each primary human cancer and cell line

✍ Scribed by Yoshinori Murakami; Takao Sekiya


Book ID
114072269
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
109 KB
Volume
400
Category
Article
ISSN
0027-5107

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A competitive polymerase chain reaction has been developed for quantitation of BRCA1 mRNA. In human cancer cell lines, the amount of BRCA1 mRNA is relatively low, ranging from 6 to 38 copies per cell. The decay rate of these transcripts in actinomycin-treated cells indicates that the half-life of th