The ability of lonidamine, an energolytic derivative of indazolecarboxylic acid, to modulate the cytotoxicity of cisplatin was investigated in human ovarian-cancer cell lines sensitive (A2780) or with experimentally induced resistance (A2780/cp8) to the alkylating agent. A 24-hr post-incubation with
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Accumulation and photodynamic activity of chlorin e6 in cisplatin-resistant human lung cancer cells
โ Scribed by Sayo Horibe; Junya Nagai; Ryoko Yumoto; Riichi Tawa; Mikihisa Takano
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 221 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that the activity and expression of Na^+^