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Accumulating Active p53 in the Nucleus by Inhibition of Nuclear Export: A Novel Strategy to Promote the p53 Tumor Suppressor Function

✍ Scribed by Sonia Laı́n; Dimitris Xirodimas; David P. Lane


Book ID
115603475
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
72 KB
Volume
253
Category
Article
ISSN
0014-4827

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula