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Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism

✍ Scribed by Marianne S. Poruchynsky; Paraskevi Giannakakou; Yvona Ward; J. Chloe Bulinski; William G. Telford; Robert W. Robey; Tito Fojo

Book ID
113992830
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
416 KB
Volume
62
Category
Article
ISSN
0006-2952

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## Abstract The human lung carcinoma cell line DLKP was exposed to sequential pulses of 10 commonly used chemotherapeutic drugs (VP‐16, vincristine, taxotere, mitoxantrone, 5‐fluorouracil, methotrexate, CCNU, BCNU, cisplatin and chlorambucil); resulting cell lines exhibited resistance to the select