✦ LIBER ✦
Accessory protein function in the DNA polymerase III holoenzyme from E. coli
✍ Scribed by Mike O'Donnell
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 649 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.